Seroprevalence of hepatitis C virus markers in multi-transfused children with beta-thalassemia
نویسندگان
چکیده
Background To study the seroprevalence of hepatitis C virus in multi-transfused children with b-thalassemia and compared with non transfused children and healthy controls. b-thalassemic children fail to thrive, with growth and developmental retardation and suffer microcytic hypochromic anemia. Since regular blood transfusions are given to maintain haemoglobin at a safe level, these children are at a high risk of acquiring hepatitis C virus through transfusions.
منابع مشابه
The Prevalence of Hepatitis B, Hepatitis C, and Human Immunodeficiency Virus Infections among β-thalassemia Major: A Multicenter Survey in Lorestan, West of Iran
Background: Although regular frequent blood transfusion improves overall survival of multi-transfused patients like β-thalassemic ones, it carries a definite risk of infection with blood-borne viruses such as viral hepatitis. This study was done to determine seropositivity of hepatitis B virus (HBV), hepatitis C virus (HCV), and Human Immunedeficiency Virus (HIV) infections among β-th...
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Hepatitis C virus (HCV) infection is highly prevalent in thalassemic patients, and this may decrease the serum antibody response to hepatitis B virus (HBV) vaccine. There is also some alteration of the immune system in multi-transfused thalassemic patients, as a consequence of iron overload. We investigated whether HCY infection may reduce the effectiveness of HBY vaccine in multi - transf...
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Background: Transfusion-transmi!ed infec"ons (TTIs) con"nue to be a problem in many parts of the world and mul"-transfused pa"ents are at a par"cularly increased risk for TTIs. The aim of this study was to determine the prevalence of Hepa""s C, Hepa""s B, and human immunodeficiency virus (HIV) infec"ons among mul"-transfused pa"ents in Khuzestan Province. Materials and Methods: A cross-sec"onal...
متن کاملSeroprevalence of Hepatitis B, Hepatitis C and Human
Abstract Background Thalassemia patients that are conventionally treated by a regular transfusion regimen are exposed to blood born viral infections.The aim of this study was to investigate the seroprevalence of hepatitis B virus (HBV), hepatitis C virus (HCV) , and human Immunodeficiency virus(HIV) among all multitransfused thalassemia patients in west north of Iran. Material and methods A...
متن کاملRisks of seroconversion of hepatitis B, hepatitis C and human immunodeficiency viruses in children with multitransfused thalassaemia major.
OBJECTIVES To estimate the risks of seroconversion of hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency viruses (HIV) in children with multitransfused thalassaemia at a thalassaemic clinic in Kuala Lumpur, Malaysia. METHODS Seventy-two children (39 males, median age 11.3 years, 2.5th-97.5th centile: 1.4-19.2 years) with thalassaemia major were studied. The risks of s...
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